Since its inception in 1994, the Sistonen Lab aims at revealing the fundamental mechanisms that regulate gene expression and chromatin structure in response to intracellular and environmental signals. We have demonstrated that heat shock transcription factors (HSFs) act as integrators in cell stress, reproduction, and cancer.
The research being made in our lab:
Principal Investigator × Principal Investigator Lea Sistonen Professor of Molecular Cell Biology Publications lea.sistonen[at]btk.fi, lea.sistonen[at]abo.fi Photo by Nicklas Hägen Senior Researchers and Postdoctoral Fellows × Eva Henriksson eva.henriksson[at]abo.fi I am investigating how HSFs regulate a developmental process, i.e. spermatogenesis, and how they sustain malignant growth in cancer and promote cancer cell invasion. My special focus…
We are happy to announce that our latest publication in collaboration with Anniina Vihervaara, Assistant Professor in Gene Technology at KTH Royal Institute of Technology, is out now in Molecular Cell! A summary of the study can be found here: https://www.kth.se/en/aktuellt/nyheter/study-shows-survival-mechanism-for-cells-under-stress-1.1061825