Since its inception in 1994, the Sistonen Lab aims at revealing the fundamental mechanisms that regulate gene expression and chromatin structure in response to intracellular and environmental signals. We have demonstrated that heat shock transcription factors (HSFs) act as integrators in cell stress, reproduction, and cancer.
The research being made in our lab:
Principal Investigator Senior Researchers and Postdoctoral Fellows PhD Students Previous Lab Members Anna AaltoJohanna AhlskogTero-Pekka AlastaloJulius AnckarSusanna AiraksinenJudith BeerHeidi BergmanJohanna BjörkMalin BlomHenri BlomsterMarek BudzyńskiIdalis CardonaZhanna ChitikovaAlexandra ElsingCaroline Haldin-BreitensteinVille HietakangasSamu HimanenCarina HolmbergMaria JensenJenny Joutsen Lila Kallio (neé Pirkkala)Sara KangaspeskaEmine LundstenHeidi LustigTerhi Maula (neé Kuru)Annika MeinanderSatu OrasniemiBeata PaziewskaMarkus PenttinenSandra PihlströmJulia RantaHelena SaarentoAnton SandqvistCynthia SwanPetra VainioJenni VasaraAnniina VihervaaraMalin…
New publication out in Nucleic Acids Research!
STRESS-SPECIFIC GENOME-WIDE PROGRAMS OF GENES AND ENHANCERS Cells are exposed to various types of cytotoxic stress including oxidative stress, elevated temperatures and toxins. Surviving stressful conditions requires extensive reprogramming of transcription, which involves both upregulation and downregulation of genes. Heat shock has provided an excellent model to investigate how nascent transcription is regulated in cells…