The research being made in our lab:
Research
Cellular Stress Responses
Proteotoxic stresses
HPV Horizon
Human papillomavirus (HPV) infection is a major global health issue. HPV infection is a well-established cause of cervical cancer and a relevant factor in other anogenital cancers as well as head and neck cancers. One common denominator of the HPV genotypes is the E6 and E7 proteins, which are mainly responsible for malignant and non-malignant…
EXTRACELLULAR VESICLES
Extracellular vesicles (EVs) are membrane surrounded structures released by cells in an evolutionally conserved manner. EVs are both heterogenous in size and nature. Exosomes, small EVs of 30-100 nm in diameter, are formed through inward budding of late endosomes/multivesicular bodies (MVBs) which then are released into the extracellular space once the MVB fuses with the…
Small Molecular Inhibitors
Small molecular inhibitors against the heat shock response
Post-Translational Modifications
Post-translational modifications of HSFs
Methods
Methods used in our lab
Sistonen Lab 